Reaction Details |
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Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
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Ligand | BDBM50061901 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_155184 (CHEMBL761831) |
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IC50 | 100.0±n/a nM |
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Citation | Xia, Y; Chackalamannil, S; Czarniecki, M; Tsai, H; Vaccaro, H; Cleven, R; Cook, J; Fawzi, A; Watkins, R; Zhang, H Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. J Med Chem40:4372-7 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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cGMP-specific 3',5'-cyclic phosphodiesterase |
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Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
Synonyms: | PDE5 | PDE5A | PDE5A_BOVIN | Phosphodiesterase 5A |
Type: | PROTEIN |
Mol. Mass.: | 98615.45 |
Organism: | Bos taurus |
Description: | ChEMBL_155186 |
Residue: | 865 |
Sequence: | MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN
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BDBM50061901 |
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n/a |
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Name | BDBM50061901 |
Synonyms: | (+)(6aR,9aS)-5,6a,7,8,9,9a-Hexahydro-2,5-dimethyl-3-(phenylmethyl)cyclopetn[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one | (+/-)Rac-(6aR*,9aS*)-5,6a,7,8,9,9a-Hexahydro-2,5-dimethyl-3-(phenylmethyl)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(1H)-one | CHEMBL140173 |
Type | Small organic molecule |
Emp. Form. | C19H21N5O |
Mol. Mass. | 335.4029 |
SMILES | CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(C)c(Cc3ccccc3)c2C1=O |t:2| |
Structure |
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