| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM50054139 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1837184 (CHEMBL4337317) |
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| Ki | 32±n/a nM |
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| Citation |  Cheng, HWA; Sokias, R; Werry, EL; Ittner, LM; Reekie, TA; Du, J; Gao, Q; Hibbs, DE; Kassiou, M First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold. J Med Chem62:8235-8248 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 18834.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30536 |
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| Residue: | 169 |
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| Sequence: | MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA
ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
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| BDBM50054139 |
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| n/a |
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| Name | BDBM50054139 |
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| Synonyms: | (R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic acid sec-butyl-methyl-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN2O |
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| Mol. Mass. | 352.857 |
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| SMILES | CC[C@@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl |
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| Structure | 
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