| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial |
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| Ligand | BDBM50400050 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1837821 (CHEMBL4337954) |
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| IC50 | 3300±n/a nM |
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| Citation |  Xu, X; Kuang, Z; Han, J; Meng, Y; Li, L; Luan, H; Xu, P; Wang, J; Luo, C; Ding, H; Li, Z; Bian, J Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors. J Med Chem62:9642-9657 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminase kidney isoform, mitochondrial |
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| Name: | Glutaminase kidney isoform, mitochondrial |
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| Synonyms: | 3.5.1.2 | GLSK_RAT | Gls | Glutaminase kidney isoform, mitochondrial | Glutaminase kidney isoform, mitochondrial 65 kDa chain | Glutaminase kidney isoform, mitochondrial 68 kDa chain | K-glutaminase | L-glutamine amidohydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74035.00 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_118936 |
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| Residue: | 674 |
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| Sequence: | MMRLRGSAMLRELLLRPPAAVGGVLRRTQPLGTLCRRPRGGSRPAAGLVAAARLHPWWGG
GGRAKGPGSGGLSSSPSEILQELGKGGTPPQQQQQQQQQPGASPPAAPGPKDSPGETDAF
GNSEGKEMVAAGDNKVKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRL
KECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELY
ESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSIGDTKVPFCLQSCVKPLKYAI
AVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKF
DYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYF
QLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFH
VGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRH
FAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAA
EGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDDG
KENQTVHKNLDGLL
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| BDBM50400050 |
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| n/a |
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| Name | BDBM50400050 |
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| Synonyms: | CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732, Example BPTES | US8604016, 1 | US9938267, Cmpd ID 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24N6O2S3 |
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| Mol. Mass. | 524.681 |
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| SMILES | O=C(Cc1ccccc1)Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1 |
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| Structure | 
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