| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial |
|---|
| Ligand | BDBM50509186 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1837827 (CHEMBL4337960) |
|---|
| IC50 | 760±n/a nM |
|---|
| Citation |  Xu, X; Kuang, Z; Han, J; Meng, Y; Li, L; Luan, H; Xu, P; Wang, J; Luo, C; Ding, H; Li, Z; Bian, J Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors. J Med Chem62:9642-9657 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutaminase kidney isoform, mitochondrial |
|---|
| Name: | Glutaminase kidney isoform, mitochondrial |
|---|
| Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 73471.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O94925 |
|---|
| Residue: | 669 |
|---|
| Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
|
|
|
|---|
| BDBM50509186 |
|---|
| n/a |
|---|
| Name | BDBM50509186 |
|---|
| Synonyms: | CHEMBL4436657 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H31N9O3S2 |
|---|
| Mol. Mass. | 617.745 |
|---|
| SMILES | COc1ccc(Cn2cc(CCC(=O)Nc3nnc(CCCCc4nnc(NC(=O)Cc5ccccc5)s4)s3)nn2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
