| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 7 |
|---|
| Ligand | BDBM50509365 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1838061 (CHEMBL4338194) |
|---|
| IC50 | 1200±n/a nM |
|---|
| Citation |  Hansen, KØ; Andersen, JH; Bayer, A; Pandey, SK; Lorentzen, M; Jørgensen, KB; Sydnes, MO; Guttormsen, Y; Baumann, M; Koch, U; Klebl, B; Eickhoff, J; Haug, BE; Isaksson, J; Hansen, EH Kinase Chemodiversity from the Arctic: The Breitfussins. J Med Chem62:10167-10181 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 7 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 7 |
|---|
| Synonyms: | M3K7_HUMAN | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TAK1/TAB1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1 (TAK1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 67199.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O43318 |
|---|
| Residue: | 606 |
|---|
| Sequence: | MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN
ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
KRQGTS
|
|
|
|---|
| BDBM50509365 |
|---|
| n/a |
|---|
| Name | BDBM50509365 |
|---|
| Synonyms: | CHEMBL4564337 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12BrN3O2 |
|---|
| Mol. Mass. | 358.189 |
|---|
| SMILES | COc1cc2c(c[nH]c2cc1Br)-c1cnc(o1)-c1ccc[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
