Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50064044 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55239 (CHEMBL666993) |
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IC50 | 970±n/a nM |
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Citation | Gangjee, A; Elzein, E; Queener, SF; McGuire, JJ Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases. J Med Chem41:1409-16 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 19884.75 |
Organism: | Mycobacterium avium |
Description: | Recombinant Mycobacterium avium DHFR expressed in E. coli. |
Residue: | 181 |
Sequence: | MTRAEVGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRP
LPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEV
TEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRP
S
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BDBM50064044 |
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n/a |
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Name | BDBM50064044 |
Synonyms: | (S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid | CHEMBL418214 |
Type | Small organic molecule |
Emp. Form. | C22H24N6O6 |
Mol. Mass. | 468.4626 |
SMILES | Nc1nc(N)c2c3CCN(Cc4ccc(cc4)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc3oc2n1 |
Structure |
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