| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50064042 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_55239 (CHEMBL666993) |
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| IC50 | >20000±n/a nM |
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| Citation |  Gangjee, A; Elzein, E; Queener, SF; McGuire, JJ Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases. J Med Chem41:1409-16 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 19884.75 |
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| Organism: | Mycobacterium avium |
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| Description: | Recombinant Mycobacterium avium DHFR expressed in E. coli. |
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| Residue: | 181 |
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| Sequence: | MTRAEVGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRP
LPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSDPAPWVIGGAQIYLLALPHATRCEV
TEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRP
S
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| BDBM50064042 |
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| n/a |
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| Name | BDBM50064042 |
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| Synonyms: | 7-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[4',3':4,5]furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL31273 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15Cl2N5O |
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| Mol. Mass. | 364.229 |
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| SMILES | Nc1nc(N)c2c3CCN(Cc4ccc(Cl)c(Cl)c4)Cc3oc2n1 |
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| Structure | 
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