| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50510063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1840028 (CHEMBL4340243) |
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| Ki | 8.7±n/a nM |
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| Citation |  Nocentini, A; Lucidi, A; Perut, F; Massa, A; Tomaselli, D; Gratteri, P; Baldini, N; Rotili, D; Mai, A; Supuran, CT ?,?-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors. ACS Med Chem Lett10:661-665 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50510063 |
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| n/a |
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| Name | BDBM50510063 |
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| Synonyms: | CHEMBL4568798 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17NO5 |
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| Mol. Mass. | 387.3848 |
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| SMILES | OC(=O)C(\O)=C\C(=O)\C=C\c1ccc(NC(=O)c2cccc3ccccc23)cc1 |
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| Structure | 
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