| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl 3-hydroxylase OGFOD1 |
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| Ligand | BDBM107704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1840412 (CHEMBL4340711) |
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| IC50 | 1400±n/a nM |
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| Citation |  Langley, GW; Abboud, MI; Lohans, CT; Schofield, CJ Inhibition of a viral prolyl hydroxylase. Bioorg Med Chem27:2405-2412 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl 3-hydroxylase OGFOD1 |
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| Name: | Prolyl 3-hydroxylase OGFOD1 |
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| Synonyms: | 1.14.11.- | 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 | KIAA1612 | OGFD1_HUMAN | OGFOD1 | Prolyl 3-hydroxylase OGFOD1 | TPA1 | Termination and polyadenylation 1 homolog | uS12 prolyl 3-hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63220.24 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119148 |
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| Residue: | 542 |
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| Sequence: | MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDP
FLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILF
EDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGG
TLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISGWFHGP
SLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLK
PEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEALFLLLSNF
TGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPE
PEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTS
YIAKGEDEELLTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIY
YE
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| BDBM107704 |
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| n/a |
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| Name | BDBM107704 |
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| Synonyms: | US11426393, Compound Table XV.11 | US8598210, 119 | US8598210, Table XV, 10 | US8598210, Table XV, 11 | US8722895, 10: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid trifluoroacetic acid salt | US8722895, 11: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid | US9598370, Example 00136 | USRE47437, Example {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11ClN2O4 |
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| Mol. Mass. | 306.701 |
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| SMILES | OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1 |
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| Structure | 
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