Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Ligand | BDBM50511124 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1843886 (CHEMBL4344313) |
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Ki | 74±n/a nM |
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Citation | Kump, KJ; Miao, L; Mady, ASA; Ansari, NH; Shrestha, UK; Yang, Y; Pal, M; Liao, C; Perdih, A; Abulwerdi, FA; Chinnaswamy, K; Meagher, JL; Carlson, JM; Khanna, M; Stuckey, JA; Nikolovska-Coleska, Z Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. J Med Chem63:2489-2510 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
Type: | Membrane; Single-pass membrane protein |
Mol. Mass.: | 37332.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07820 |
Residue: | 350 |
Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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BDBM50511124 |
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n/a |
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Name | BDBM50511124 |
Synonyms: | CHEMBL4533559 |
Type | Small organic molecule |
Emp. Form. | C30H37N3O5S2 |
Mol. Mass. | 583.762 |
SMILES | COc1cccc(CCSc2ccc(NS(=O)(=O)N3CCN(CC3)c3ccc(cc3)C(C)(C)C)c(c2)C(O)=O)c1 |
Structure |
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