Ki Summary

Reaction Details

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Target

C5a anaphylatoxin chemotactic receptor 1

Ligand

BDBM50066481

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_157422 (CHEMBL768878)

IC50

12±n/a nM

Citation

Wong, AK; Finch, AM; Pierens, GK; Craik, DJ; Taylor, SM; Fairlie, DP Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a. J Med Chem41:3417-25 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

C5a anaphylatoxin chemotactic receptor 1

Name:

C5a anaphylatoxin chemotactic receptor 1

Synonyms:

C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88

Type:

Enzyme

Mol. Mass.:

39347.68

Organism:

Homo sapiens (Human)

Description:

P21730

Residue:

350

Sequence:

MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV

BDBM50066481

n/a

Name

BDBM50066481

Synonyms:

(S)-2-Acetylamino-N-[(5S,11R,14S,17R,19aS)-17-cyclohexylmethyl-11-(3-guanidino-propyl)-14-(1H-indol-3-ylmethyl)-4,10,13,16,19-pentaoxo-icosahydro-3a,9,12,15,18-pentaaza-cyclopentacyclooctadecen-5-yl]-3-phenyl-propionamide | CHEMBL115478

Type

Small organic molecule

Emp. Form.

C47H65N11O7

Mol. Mass.

896.0885

SMILES

CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCNC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C1=O

Structure