| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Ligand | BDBM50512138 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1847903 (CHEMBL4348444) |
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| IC50 | 130±n/a nM |
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| Citation |  Lu, GQ; Li, XY; Mohamed O, K; Wang, D; Meng, FH Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs. Eur J Med Chem171:282-296 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15B |
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| Synonyms: | Alox15b | Arachidonate 15-lipoxygenase, type II | LX15B_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76140.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_12426 |
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| Residue: | 677 |
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| Sequence: | MAKFRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKEFSAGAEEDFEVTLPQD
VGTVLMLRIHKAPPEAPLPLLSFPPDAWYCRWFELEWLPGAALRFPCYQWLEGAGELVLR
EGAAKVSWQDHHRTLQDQRQKELESRKDMYSWKTYIEGWPHCLDHETVKDLDLNIKYSAM
KNAKFFFKAQSAFTELKFKGLLDRTGLWRSLREMKRMFNFHNTPAAEYVFAHWQEDAFFA
SQFLNGLNPVLIRRCRRLPENFPVTDEMVAPVLGPGTSLQAELEKGSLFLVDHGILSGVQ
TNVINGKPQFSAAPMTLLYQSPGSGPLLPIAIQLKQTPGPDNPIFLPSDDKWDWLLAKTW
VRNAEFSIHEALTHLLHAHLIPEVFALATLRQLPHCHPLFKLLIPHTRYTLHINTLAREL
LIAPGKVVDKSTGLGIGGFSDLIKRNMEQLSYSVLCLPEDIRARDVGDLPGYYYRDDGMQ
IWSAIRSFVSEIVDIYYPSDASVRDDQELQAWVGEIFSEGFLSQESSGMPSLLDTQEALV
QYVTMVIFTCSAKHAAVSASQFDSCVWMPNLPPSMQLPPPTSKGQASPEGFIATLPAVNA
TCDVIIALWLLSKEPGDRRPLGHYPDEHFTEEVPRRSIAAFQRKLIQISSGIRKRNQSLA
LPYTYLDPPLIENSVSI
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| BDBM50512138 |
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| n/a |
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| Name | BDBM50512138 |
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| Synonyms: | CHEMBL4550585 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13ClN6O4S |
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| Mol. Mass. | 444.852 |
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| SMILES | Clc1ccc(cc1)-n1cc(nn1)-c1ccccc1NS(=O)(=O)c1c[nH]c(=O)[nH]c1=O |
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| Structure | 
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