| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Ligand | BDBM144390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1849286 (CHEMBL4349827) |
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| IC50 | >10000±n/a nM |
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| Citation |  Koizumi, Y; Tanaka, Y; Matsumura, T; Kadoh, Y; Miyoshi, H; Hongu, M; Takedomi, K; Kotera, J; Sasaki, T; Taniguchi, H; Watanabe, Y; Takakuwa, M; Kojima, K; Baba, N; Nakamura, I; Kawanishi, E Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem27:3440-3450 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Type: | Enzyme |
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| Mol. Mass.: | 51842.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NP56 |
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| Residue: | 450 |
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| Sequence: | MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
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| BDBM144390 |
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| n/a |
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| Name | BDBM144390 |
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| Synonyms: | US8969376, 1.006 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25F2N7O |
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| Mol. Mass. | 453.4877 |
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| SMILES | Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| |
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| Structure | 
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