| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Ligand | BDBM144390 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1849288 (CHEMBL4349829) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Koizumi, Y; Tanaka, Y; Matsumura, T; Kadoh, Y; Miyoshi, H; Hongu, M; Takedomi, K; Kotera, J; Sasaki, T; Taniguchi, H; Watanabe, Y; Takakuwa, M; Kojima, K; Baba, N; Nakamura, I; Kawanishi, E Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem27:3440-3450 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68488.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O76083 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
|
|
|
|---|
| BDBM144390 |
|---|
| n/a |
|---|
| Name | BDBM144390 |
|---|
| Synonyms: | US8969376, 1.006 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25F2N7O |
|---|
| Mol. Mass. | 453.4877 |
|---|
| SMILES | Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
