Reaction Details |
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Target | Polyphenol oxidase 2 |
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Ligand | BDBM50513188 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1852183 (CHEMBL4352807) |
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IC50 | 72300±n/a nM |
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Citation | Piechowska, K; ?witalska, M; Cytarska, J; Jaroch, K; ?uczykowski, K; Cha?upka, J; Wietrzyk, J; Misiura, K; Bojko, B; Kruszewski, S; ??czkowski, KZ Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination. Eur J Med Chem175:162-171 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyphenol oxidase 2 |
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Name: | Polyphenol oxidase 2 |
Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
Type: | Protein |
Mol. Mass.: | 63923.66 |
Organism: | Agaricus bisporus (Common mushroom) |
Description: | O42713 |
Residue: | 556 |
Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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BDBM50513188 |
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n/a |
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Name | BDBM50513188 |
Synonyms: | CHEMBL4453112 |
Type | Small organic molecule |
Emp. Form. | C17H19N7S |
Mol. Mass. | 353.445 |
SMILES | [H][C@]12CC[C@]([H])(C\C(C1)=N/Nc1nc(cs1)-c1ccc(cc1)N=[N+]=[N-])N2C |r,TLB:9:7:25:2.3| |
Structure |
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