| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
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| Ligand | BDBM50046866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1853675 (CHEMBL4354299) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Tzvetkov, NT; Stammler, HG; Georgieva, MG; Russo, D; Faraone, I; Balacheva, AA; Hristova, S; Atanasov, AG; Milella, L; Antonov, L; Gastreich, M Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors. Eur J Med Chem179:404-422 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] B |
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| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58469.65 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P19643 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
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| BDBM50046866 |
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| n/a |
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| Name | BDBM50046866 |
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| Synonyms: | CHEMBL3319256 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11Cl2N3O |
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| Mol. Mass. | 320.173 |
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| SMILES | Cn1ncc2cc(ccc12)C(=O)Nc1ccc(Cl)c(Cl)c1 |
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| Structure | 
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