| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin IV [1-448] |
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| Ligand | BDBM50513846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1854568 (CHEMBL4355297) |
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| IC50 | 90±n/a nM |
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| Citation |  Bobrovs, R; Jaudzems, K; Jirgensons, A Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases. J Med Chem62:8931-8950 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin IV [1-448] |
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| Name: | Plasmepsin IV [1-448] |
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| Synonyms: | PLM4_PLAF7 | PMIV | Plasmepsin 4 (PM-IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50925.00 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q8IM16[1-448] |
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| Residue: | 448 |
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| Sequence: | MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGN
FYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYL
GSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYD
ASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSE
FDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYE
GPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKV
PFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTF
ILGDPFMRKYFTVFDYEKESVGFAVAKN
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| BDBM50513846 |
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| n/a |
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| Name | BDBM50513846 |
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| Synonyms: | CHEMBL4456145 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N2O2S |
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| Mol. Mass. | 490.7 |
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| SMILES | CC(C)CCCCc1ccc(cc1)S(=O)(=O)C1C2CCC(N2)C1NCc1ccc2ccccc2c1 |TLB:23:22:21:19.18,THB:13:16:21:19.18| |
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| Structure | 
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