Reaction Details |
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Target | 5-hydroxytryptamine receptor 1B |
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Ligand | BDBM50033383 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1597 (CHEMBL616624) |
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EC50 | 16±n/a nM |
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Citation | Perez, M; Pauwels, PJ; Fourrier, C; Chopin, P; Valentin, JP; John, GW; Marien, M; Halazy, S Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist. Bioorg Med Chem Lett8:675-80 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1B |
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Name: | 5-hydroxytryptamine receptor 1B |
Synonyms: | 5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 43579.17 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells |
Residue: | 390 |
Sequence: | MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL
KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE
KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL
NSLINPIIYTMSNEDFKQAFHKLIRFKCTS
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BDBM50033383 |
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n/a |
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Name | BDBM50033383 |
Synonyms: | (S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one | (S)-4-[3-(2-Dimethylamino-ethyl)-1H-indol-5-ylmethyl]-oxazolidin-2-one | 311C90 | CHEMBL1185 | ZOLMITRIPTAN | ZOMIG | ZOMIG-ZMT |
Type | Small organic molecule |
Emp. Form. | C16H21N3O2 |
Mol. Mass. | 287.3568 |
SMILES | CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12 |
Structure |
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