| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 14 |
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| Ligand | BDBM50437694 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1855683 (CHEMBL4356412) |
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| IC50 | 12300±n/a nM |
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| Citation |  Schauer, NJ; Magin, RS; Liu, X; Doherty, LM; Buhrlage, SJ Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. J Med Chem63:2731-2750 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 14 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 14 |
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| Synonyms: | Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56058.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103728 |
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| Residue: | 494 |
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| Sequence: | MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN
IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV
QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH
MAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKK
SLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK
QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCT
PELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDL
QAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLY
GPRRVEIMEEESEQ
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| BDBM50437694 |
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| n/a |
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| Name | BDBM50437694 |
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| Synonyms: | CHEMBL1410015 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21FN2O |
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| Mol. Mass. | 300.3705 |
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| SMILES | Cc1cc(C(=O)CN2CCCC2)c(C)n1-c1ccc(F)cc1 |
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| Structure | 
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