| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 2 |
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| Ligand | BDBM50514116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1855684 (CHEMBL4356413) |
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| IC50 | 9700±n/a nM |
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| Citation |  Schauer, NJ; Magin, RS; Liu, X; Doherty, LM; Buhrlage, SJ Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. J Med Chem63:2731-2750 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 2 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 2 |
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| Synonyms: | 41 kDa ubiquitin-specific protease | Deubiquitinating enzyme 2 | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin thioesterase 2 | Ubiquitin-specific-processing protease 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68093.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103660 |
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| Residue: | 605 |
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| Sequence: | MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFL
TRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNN
CLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELC
TLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETG
KGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLY
MRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQE
FLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLK
SSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCR
GRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAV
YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELAS
PPSRM
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| BDBM50514116 |
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| n/a |
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| Name | BDBM50514116 |
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| Synonyms: | CHEMBL4458718 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H43NO3 |
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| Mol. Mass. | 405.6138 |
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| SMILES | [H][C@@]1(CC[C@]2([H])[C@]1(C)CC[C@@]1([H])[C@@]2(C)CC[C@]2([H])C[C@H](O)CC[C@]12C)[C@H](C)CCC(=O)NO |r| |
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| Structure | 
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