| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melanocortin receptor 3 |
|---|
| Ligand | BDBM50514452 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1856753 (CHEMBL4357482) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. J Med Chem63:2194-2208 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melanocortin receptor 3 |
|---|
| Name: | Melanocortin receptor 3 |
|---|
| Synonyms: | MC3-R | MC3R_MOUSE | Mc3r |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35808.24 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_1498848 |
|---|
| Residue: | 323 |
|---|
| Sequence: | MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVI
LAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIF
DSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFI
IYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFKEILCGCNSMNLG
|
|
|
|---|
| BDBM50514452 |
|---|
| n/a |
|---|
| Name | BDBM50514452 |
|---|
| Synonyms: | CHEMBL4466724 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C50H64N12O10 |
|---|
| Mol. Mass. | 993.1176 |
|---|
| SMILES | [H][C@@]12CCCN1C(=O)[C@@]1([H])CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC2=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
