| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 5 |
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| Ligand | BDBM50514459 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1856759 (CHEMBL4357488) |
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| IC50 | 36000±n/a nM |
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| Citation |  Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists. J Med Chem63:2194-2208 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 5 |
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| Name: | Melanocortin receptor 5 |
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| Synonyms: | MC5R_MOUSE | Mc5r | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36966.58 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P41149 |
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| Residue: | 325 |
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| Sequence: | MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGA
IVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDS
MICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIY
YESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITL
TMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQ
EMRRTFKEIVCCHGFRRPCRLLGGY
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| BDBM50514459 |
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| n/a |
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| Name | BDBM50514459 |
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| Synonyms: | CHEMBL4566163 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H64N12O9 |
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| Mol. Mass. | 965.1075 |
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| SMILES | [H][C@@]12CCCN1C(=O)[C@@]1([H])CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC2=O |r| |
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| Structure | 
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