| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50514754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1858299 (CHEMBL4359028) |
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| IC50 | 413±n/a nM |
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| Citation |  Serafini, M; Torre, E; Aprile, S; Grosso, ED; Gesł, A; Griglio, A; Colombo, G; Travelli, C; Paiella, S; Adamo, A; Orecchini, E; Coletti, A; Pallotta, MT; Ugel, S; Massarotti, A; Pirali, T; Fallarini, S Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to J Med Chem63:3047-3065 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50514754 |
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| n/a |
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| Name | BDBM50514754 |
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| Synonyms: | CHEMBL4588288 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19N3O2 |
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| Mol. Mass. | 381.4266 |
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| SMILES | O=C(NCc1cccc(Cn2cnc3ccccc23)c1)c1cc2ccccc2o1 |
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| Structure | 
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