Reaction Details |
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Target | Polyphenol oxidase 2 |
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Ligand | BDBM50515003 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1859560 (CHEMBL4360416) |
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IC50 | 1490±n/a nM |
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Citation | Ielo, L; Deri, B; Germanò, MP; Vittorio, S; Mirabile, S; Gitto, R; Rapisarda, A; Ronsisvalle, S; Floris, S; Pazy, Y; Fais, A; Fishman, A; De Luca, L Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. Eur J Med Chem178:380-389 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyphenol oxidase 2 |
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Name: | Polyphenol oxidase 2 |
Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
Type: | Protein |
Mol. Mass.: | 63923.66 |
Organism: | Agaricus bisporus (Common mushroom) |
Description: | O42713 |
Residue: | 556 |
Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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BDBM50515003 |
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n/a |
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Name | BDBM50515003 |
Synonyms: | CHEMBL4549197 |
Type | Small organic molecule |
Emp. Form. | C18H19FN2O3 |
Mol. Mass. | 330.3535 |
SMILES | Oc1ccc(C(=O)N2CCN(Cc3ccc(F)cc3)CC2)c(O)c1 |
Structure |
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