| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
|---|
| Ligand | BDBM50515015 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1859560 (CHEMBL4360416) |
|---|
| IC50 | 3120±n/a nM |
|---|
| Citation |  Ielo, L; Deri, B; Germanò, MP; Vittorio, S; Mirabile, S; Gitto, R; Rapisarda, A; Ronsisvalle, S; Floris, S; Pazy, Y; Fais, A; Fishman, A; De Luca, L Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile. Eur J Med Chem178:380-389 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyphenol oxidase 2 |
|---|
| Name: | Polyphenol oxidase 2 |
|---|
| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63923.66 |
|---|
| Organism: | Agaricus bisporus (Common mushroom) |
|---|
| Description: | O42713 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
|
|
|
|---|
| BDBM50515015 |
|---|
| n/a |
|---|
| Name | BDBM50515015 |
|---|
| Synonyms: | CHEMBL4470032 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18ClFN2O |
|---|
| Mol. Mass. | 332.8 |
|---|
| SMILES | Fc1ccc(CN2CCN(CC2)C(=O)c2ccccc2Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
