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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50515640
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1861960 (CHEMBL4362816)
Ki 6.0±n/a nM
Citation Neochoritis, CG; Atmaj, J; Twarda-Clapa, A; Surmiak, E; Skalniak, L; Köhler, LM; Muszak, D; Kurpiewska, K; Kalinowska-T?u?cik, J; Beck, B; Holak, TA; Dömling, A Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction. Eur J Med Chem182:0 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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  Blast E-value cutoff:
BDBM50515640
n/a
NameBDBM50515640
Synonyms:CHEMBL4532127
TypeSmall organic molecule
Emp. Form.C36H37BrClN3O5
Mol. Mass.707.053
SMILES[H][C@]12CC[C@@](C)(C(C1)NC(=O)C(N(Cc1ccc(OCc3ccccc3Br)cc1)C=O)c1c([nH]c3cc(Cl)ccc13)C(O)=O)C2(C)C |r,TLB:8:6:44:2.3|
Structure
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