Reaction Details |
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Target | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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Ligand | BDBM50516122 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1863301 (CHEMBL4364157) |
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IC50 | 290±n/a nM |
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Citation | Lu, T; Connolly, PJ; Philippar, U; Sun, W; Cummings, MD; Barbay, K; Gys, L; Van Nuffel, L; Austin, N; Bekkers, M; Shen, F; Cai, A; Attar, R; Meerpoel, L; Edwards, J Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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Name: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
Synonyms: | MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase |
Type: | Enzyme |
Mol. Mass.: | 92257.81 |
Organism: | Homo sapiens (Human) |
Description: | Q9UDY8 |
Residue: | 824 |
Sequence: | MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
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BDBM50516122 |
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n/a |
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Name | BDBM50516122 |
Synonyms: | CHEMBL4476038 |
Type | Small organic molecule |
Emp. Form. | C21H26ClN3O2 |
Mol. Mass. | 387.903 |
SMILES | CC[C@@H]1C[C@@H](CCN1c1ncccc1C)C(=O)Nc1ccc(OC)c(Cl)c1 |r| |
Structure |
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