| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Ligand | BDBM50516107 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1863301 (CHEMBL4364157) |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Lu, T; Connolly, PJ; Philippar, U; Sun, W; Cummings, MD; Barbay, K; Gys, L; Van Nuffel, L; Austin, N; Bekkers, M; Shen, F; Cai, A; Attar, R; Meerpoel, L; Edwards, J Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Name: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
|---|
| Synonyms: | MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92257.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UDY8 |
|---|
| Residue: | 824 |
|---|
| Sequence: | MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
|
|
|
|---|
| BDBM50516107 |
|---|
| n/a |
|---|
| Name | BDBM50516107 |
|---|
| Synonyms: | CHEMBL4591083 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21BrClN3O2 |
|---|
| Mol. Mass. | 438.746 |
|---|
| SMILES | COc1ccc(NC(=O)[C@@H]2CCN([C@H](C)C2)c2ncccc2Br)cc1Cl |r| |
|---|
| Structure | 
|
|---|
Search and Browse
