| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50516291 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1864127 (CHEMBL4365102) |
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| IC50 | 300±n/a nM |
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| Citation |  Montanari, S; Mahmoud, AM; Pruccoli, L; Rabbito, A; Naldi, M; Petralla, S; Moraleda, I; Bartolini, M; Monti, B; Iriepa, I; Belluti, F; Gobbi, S; Di Marzo, V; Bisi, A; Tarozzi, A; Ligresti, A; Rampa, A Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment. Eur J Med Chem178:243-258 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50516291 |
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| n/a |
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| Name | BDBM50516291 |
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| Synonyms: | CHEMBL4454301 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27NO3 |
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| Mol. Mass. | 413.5082 |
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| SMILES | CCCCCNc1ccc(cc1)C(=O)c1c(oc2ccccc12)-c1ccc(OC)cc1 |
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| Structure | 
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