| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
|---|
| Ligand | BDBM50516625 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1866231 (CHEMBL4367206) |
|---|
| IC50 | 165±n/a nM |
|---|
| Citation |  Jackson, JJ; Ketcham, JM; Younai, A; Abraham, B; Biannic, B; Beck, HP; Bui, MHT; Chian, D; Cutler, G; Diokno, R; Hu, DX; Jacobson, S; Karbarz, E; Kassner, PD; Marshall, L; McKinnell, J; Meleza, C; Okal, A; Pookot, D; Reilly, MK; Robles, O; Shunatona, HP; Talay, O; Walker, JR; Wadsworth, A; Wustrow, DJ; Zibinsky, M Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T J Med Chem62:6190-6213 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 4 |
|---|
| Name: | C-C chemokine receptor type 4 |
|---|
| Synonyms: | C-C CKR-4 | CC-CKR-4 | CCR-4 | CCR4_MOUSE | CD_antigen=CD194 | Ccr4 | Cmkbr4 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41410.76 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_512157 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVV
VLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVG
FYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYT
EHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRA
VRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLN
PVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
|
|
|
|---|
| BDBM50516625 |
|---|
| n/a |
|---|
| Name | BDBM50516625 |
|---|
| Synonyms: | CHEMBL4459231 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H28Cl2N6O |
|---|
| Mol. Mass. | 511.446 |
|---|
| SMILES | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CC[C@@H]([C@H](C)C1)N1CCC[C@H]1CO |r,t:24| |
|---|
| Structure | 
|
|---|
Search and Browse
