Reaction Details | |||
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Target | Sodium-dependent serotonin transporter | ||
Ligand | BDBM50516843 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1867021 (CHEMBL4367996) | ||
Ki | 34±n/a nM | ||
Citation | ?lifirski, G; Król, M; Kleps, J; Podsadni, P; Belka, M; B?czek, T; Siwek, A; Stachowicz, K; Szewczyk, B; Nowak, G; Bojarski, A; Kozio?, AE; Tur?o, J; Herold, F Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT Eur J Med Chem180:383-397 (2019) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium-dependent serotonin transporter | |||
Name: | Sodium-dependent serotonin transporter | ||
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 70168.43 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | P31652 | ||
Residue: | 630 | ||
Sequence: |
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BDBM50516843 | |||
n/a | |||
Name | BDBM50516843 | ||
Synonyms: | CHEMBL4455658 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H35ClN4O2 | ||
Mol. Mass. | 531.088 | ||
SMILES | Clc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCCC(C2)c2c[nH]c3ccccc23)c1=O |(33.29,-6.1,;31.96,-5.32,;31.97,-3.79,;30.64,-3.01,;29.3,-3.78,;29.3,-5.32,;30.63,-6.09,;30.62,-7.62,;29.29,-8.39,;27.96,-7.61,;26.63,-8.39,;26.63,-9.93,;27.96,-10.69,;29.28,-9.93,;30.61,-10.7,;30.6,-12.24,;31.94,-9.94,;33.27,-10.72,;34.61,-9.96,;35.94,-10.74,;37.28,-9.97,;38.61,-10.75,;39.94,-9.99,;41.27,-10.78,;41.25,-12.32,;39.91,-13.08,;38.59,-12.3,;39.9,-14.62,;38.65,-15.51,;39.11,-16.98,;40.64,-16.99,;41.66,-18.14,;43.17,-17.84,;43.65,-16.37,;42.64,-15.23,;41.14,-15.53,;31.95,-8.4,;33.29,-7.64,)| | ||
Structure |