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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 1A | ||
| Ligand | BDBM50516849 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1867020 (CHEMBL4367995) | ||
| Ki | 142±n/a nM | ||
| Citation |  ?lifirski, G; Król, M; Kleps, J; Podsadni, P; Belka, M; B?czek, T; Siwek, A; Stachowicz, K; Szewczyk, B; Nowak, G; Bojarski, A; Kozio?, AE; Tur?o, J; Herold, F Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT Eur J Med Chem180:383-397 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 1A | |||
| Name: | 5-hydroxytryptamine receptor 1A | ||
| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A | ||
| Type: | n/a | ||
| Mol. Mass.: | 46122.49 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 422 | ||
| Sequence: |
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| BDBM50516849 | |||
| n/a | |||
| Name | BDBM50516849 | ||
| Synonyms: | CHEMBL4472972 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H37FN4O2 | ||
| Mol. Mass. | 528.6602 | ||
| SMILES | Cc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCCC(C2)c2c[nH]c3ccc(F)cc23)c1=O |(10.75,-5.73,;9.42,-4.96,;9.42,-3.42,;8.09,-2.64,;6.75,-3.42,;6.75,-4.95,;8.08,-5.72,;8.07,-7.26,;6.74,-8.03,;5.41,-7.25,;4.08,-8.03,;4.08,-9.57,;5.41,-10.33,;6.74,-9.57,;8.06,-10.34,;8.05,-11.88,;9.4,-9.58,;10.73,-10.36,;12.06,-9.59,;13.39,-10.37,;14.73,-9.61,;16.06,-10.39,;17.39,-9.63,;18.72,-10.41,;18.7,-11.96,;17.36,-12.71,;16.04,-11.93,;17.35,-14.25,;16.1,-15.14,;16.56,-16.61,;18.1,-16.62,;19.11,-17.78,;20.62,-17.47,;21.11,-16.01,;22.61,-15.7,;20.09,-14.86,;18.59,-15.17,;9.4,-8.04,;10.74,-7.28,)| | ||
| Structure | 
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