Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 1A | ||
Ligand | BDBM50516864 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1867020 (CHEMBL4367995) | ||
Ki | 47±n/a nM | ||
Citation | ?lifirski, G; Król, M; Kleps, J; Podsadni, P; Belka, M; B?czek, T; Siwek, A; Stachowicz, K; Szewczyk, B; Nowak, G; Bojarski, A; Kozio?, AE; Tur?o, J; Herold, F Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT Eur J Med Chem180:383-397 (2019) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 1A | |||
Name: | 5-hydroxytryptamine receptor 1A | ||
Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A | ||
Type: | n/a | ||
Mol. Mass.: | 46122.49 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 422 | ||
Sequence: |
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BDBM50516864 | |||
n/a | |||
Name | BDBM50516864 | ||
Synonyms: | CHEMBL4442394 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H34ClFN4O2 | ||
Mol. Mass. | 549.079 | ||
SMILES | Fc1ccc2[nH]cc(C3CCCN(CCCCn4c(=O)c(c5CCCCn5c4=O)-c4ccccc4Cl)C3)c2c1 |(66.44,-55.06,;64.93,-55.37,;64.45,-56.83,;62.94,-57.13,;61.92,-55.98,;60.39,-55.97,;59.93,-54.5,;61.18,-53.61,;61.19,-52.07,;62.53,-51.31,;62.55,-49.77,;61.22,-48.98,;59.89,-49.74,;58.56,-48.96,;57.22,-49.73,;55.89,-48.95,;54.55,-49.71,;53.23,-48.93,;53.23,-47.39,;54.57,-46.63,;51.9,-46.61,;50.57,-47.38,;49.24,-46.61,;47.91,-47.38,;47.91,-48.92,;49.24,-49.69,;50.56,-48.92,;51.89,-49.69,;51.88,-51.23,;51.91,-45.08,;50.58,-44.31,;50.58,-42.78,;51.92,-42,;53.25,-42.78,;53.24,-44.31,;54.58,-45.09,;59.87,-51.29,;62.42,-54.52,;63.92,-54.22,)| | ||
Structure |