| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 7 |
|---|
| Ligand | BDBM50517081 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1867317 (CHEMBL4368292) |
|---|
| Ki | 363±n/a nM |
|---|
| Citation |  Bozdag, M; Ferraroni, M; Ward, C; Carta, F; Bua, S; Angeli, A; Langdon, SP; Kunkler, IH; Al-Tamimi, AS; Supuran, CT Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells. Eur J Med Chem182:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 7 |
|---|
| Name: | Carbonic anhydrase 7 |
|---|
| Synonyms: | CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29664.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human cloned isozyme. |
|---|
| Residue: | 264 |
|---|
| Sequence: | MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
IHMVNNFRPPQPLKGRVVKASFRA
|
|
|
|---|
| BDBM50517081 |
|---|
| n/a |
|---|
| Name | BDBM50517081 |
|---|
| Synonyms: | CHEMBL4462083 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22ClF3N4O5S |
|---|
| Mol. Mass. | 570.968 |
|---|
| SMILES | NS(=O)(=O)c1ccc(OCCCNC(=O)c2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
