| Reaction Details |
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 | Report a problem with these data |
| Target | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Ligand | BDBM50517947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1870170 (CHEMBL4371337) |
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| IC50 | <8000±n/a nM |
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| Citation |  Chikhale, RV; Barmade, MA; Murumkar, PR; Yadav, MR Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis. J Med Chem61:8563-8593 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Name: | Decaprenylphosphoryl-beta-D-ribose oxidase |
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| Synonyms: | DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50167.60 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_116793 |
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| Residue: | 461 |
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| Sequence: | MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY
GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ
VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL
TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL
GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS
GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY
SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS
RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
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| BDBM50517947 |
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| n/a |
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| Name | BDBM50517947 |
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| Synonyms: | CHEMBL4587211 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20F3N3O3S |
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| Mol. Mass. | 451.462 |
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| SMILES | C[C@H]1COC2(CCN(CC2)c2nc(=O)c3cc(cc(-n4cccc4)c3s2)C(F)(F)F)O1 |r| |
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| Structure | 
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