| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50518099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1870528 (CHEMBL4371695) |
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| Ki | 29±n/a nM |
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| Citation |  Ortiz Zacarķas, NV; van Veldhoven, JPD; Portner, L; van Spronsen, E; Ullo, S; Veenhuizen, M; van der Velden, WJC; Zweemer, AJM; Kreekel, RM; Oenema, K; Lenselink, EB; Heitman, LH; IJzerman, AP Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2. J Med Chem61:9146-9161 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50518099 |
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| n/a |
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| Name | BDBM50518099 |
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| Synonyms: | CHEMBL4461627 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27NO3 |
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| Mol. Mass. | 341.444 |
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| SMILES | CCCC(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(C)cc1 |c:5| |
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| Structure | 
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