| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-14 |
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| Ligand | BDBM50518292 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1871065 (CHEMBL4372232) |
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| IC50 | 80±n/a nM |
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| Citation |  Cuffaro, D; Nuti, E; Gifford, V; Ito, N; Camodeca, C; Tuccinardi, T; Nencetti, S; Orlandini, E; Itoh, Y; Rossello, A Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP). Bioorg Med Chem27:196-207 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-14 |
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| Name: | Matrix metalloproteinase-14 |
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| Synonyms: | MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase |
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| Type: | Protein |
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| Mol. Mass.: | 65900.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50281 |
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| Residue: | 582 |
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| Sequence: | MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ
HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF
FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT
SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA
AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
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| BDBM50518292 |
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| n/a |
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| Name | BDBM50518292 |
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| Synonyms: | CHEMBL4442617 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H40N6O10S2 |
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| Mol. Mass. | 828.91 |
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| SMILES | ONC(=O)[C@@H](CCNC(=O)c1cccc(c1)C(=O)NCC[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(=O)NO)NS(=O)(=O)c1ccc(cc1)-c1ccccc1 |r| |
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| Structure | 
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