| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 12 |
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| Ligand | BDBM50518665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1872172 (CHEMBL4373339) |
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| IC50 | 1660±n/a nM |
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| Citation |  Wu, JW; Yin, L; Liu, YQ; Zhang, H; Xie, YF; Wang, RL; Zhao, GL Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout. Bioorg Med Chem Lett29:383-388 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 12 |
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| Name: | Solute carrier family 22 member 12 |
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| Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59638.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96S37 |
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| Residue: | 553 |
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| Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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| BDBM50518665 |
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| n/a |
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| Name | BDBM50518665 |
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| Synonyms: | CHEMBL4445587 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13Br2Cl2N5O2S2 |
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| Mol. Mass. | 638.183 |
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| SMILES | Clc1ccc(NS(=O)(=O)CSc2nnc(Br)n2Cc2ccc(Br)c3ccccc23)c(Cl)n1 |
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| Structure | 
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