Reaction Details |
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Target | Solute carrier family 22 member 12 |
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Ligand | BDBM50518675 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1872172 (CHEMBL4373339) |
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IC50 | 280±n/a nM |
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Citation | Wu, JW; Yin, L; Liu, YQ; Zhang, H; Xie, YF; Wang, RL; Zhao, GL Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout. Bioorg Med Chem Lett29:383-388 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Solute carrier family 22 member 12 |
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Name: | Solute carrier family 22 member 12 |
Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
Type: | Enzyme |
Mol. Mass.: | 59638.65 |
Organism: | Homo sapiens (Human) |
Description: | Q96S37 |
Residue: | 553 |
Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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BDBM50518675 |
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n/a |
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Name | BDBM50518675 |
Synonyms: | CHEMBL4458898 |
Type | Small organic molecule |
Emp. Form. | C19H14Br3N5O2S2 |
Mol. Mass. | 648.189 |
SMILES | Brc1nnc(SCS(=O)(=O)Nc2cccnc2Br)n1Cc1ccc(Br)c2ccccc12 |
Structure |
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