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TargetInduced myeloid leukemia cell differentiation protein Mcl-1
LigandBDBM50519027
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1873795 (CHEMBL4375084)
Ki 24000±n/a nM
Citation Szlávik, ZOndi, LCsékei, MPaczal, ASzabó, ZBRadics, GMurray, JDavidson, JChen, IDavis, BHubbard, REPedder, CDokurno, PSurgenor, ASmith, JRobertson, ALeToumelin-Braizat, GCauquil, NZarka, MDemarles, DPerron-Sierra, FClaperon, AColland, FGeneste, OKotschy, A Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J Med Chem62:6913-6924 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Induced myeloid leukemia cell differentiation protein Mcl-1
Name:Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:Membrane; Single-pass membrane protein
Mol. Mass.:37332.87
Organism:Homo sapiens (Human)
Description:Q07820
Residue:350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50519027
n/a
NameBDBM50519027
Synonyms:CHEMBL4547333
TypeSmall organic molecule
Emp. Form.C24H23N3O3S
Mol. Mass.433.523
SMILESCCc1sc2ncnc(N[C@H](C)C(O)=O)c2c1-c1ccccc1OCc1ccccc1 |r,wU:10.10,(33.92,-28.48,;33.15,-27.15,;31.61,-27.15,;30.71,-28.4,;29.24,-27.92,;27.91,-28.7,;26.57,-27.93,;26.57,-26.39,;27.9,-25.62,;27.9,-24.08,;26.56,-23.31,;26.55,-21.77,;25.23,-24.08,;23.89,-23.32,;25.23,-25.62,;29.24,-26.38,;30.71,-25.9,;31.18,-24.44,;30.15,-23.3,;30.62,-21.84,;32.13,-21.51,;33.16,-22.65,;32.69,-24.12,;33.72,-25.27,;35.23,-24.95,;36.26,-26.09,;35.78,-27.55,;36.81,-28.7,;38.32,-28.38,;38.79,-26.9,;37.76,-25.76,)|
Structure
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