| Reaction Details |
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 | Report a problem with these data |
| Target | Chloride anion exchanger |
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| Ligand | BDBM50519196 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1874151 (CHEMBL4375440) |
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| IC50 | 23±n/a nM |
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| Citation |  Lee, S; Cil, O; Haggie, PM; Verkman, AS 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem62:8330-8337 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chloride anion exchanger |
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| Name: | Chloride anion exchanger |
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| Synonyms: | Chloride anion exchanger | Down-regulated in adenoma | Dra | Protein DRA | S26A3_MOUSE | Slc26a3 | Solute carrier family 26 member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83598.25 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_119253 |
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| Residue: | 757 |
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| Sequence: | MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPI
ASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLG
TSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSG
IIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVL
ESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGC
NFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDY
PIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVA
IGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLG
LAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFA
NIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEE
LDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGL
RTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYS
TSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF
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| BDBM50519196 |
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| n/a |
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| Name | BDBM50519196 |
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| Synonyms: | CHEMBL4436134 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17F3O5 |
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| Mol. Mass. | 406.3519 |
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| SMILES | Cc1c(OCc2cccc(c2)C(F)(F)F)ccc2c(C)c(CC(O)=O)c(=O)oc12 |
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| Structure | 
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