Ki Summary

Reaction Details

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Target

Frizzled-7

Ligand

BDBM50519306

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1874882 (CHEMBL4376171)

3.9±n/a nM

Citation

Hansen, S; Nile, AH; Mehta, SC; Fuhrmann, J; Hannoush, RN Lead Optimization Yields High Affinity Frizzled 7-Targeting Peptides That Modulate J Med Chem62:7739-7750 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Frizzled-7

Name:

Frizzled-7

Synonyms:

FZD7 | FZD7_HUMAN | Frizzled-7 | Fz-7 | FzE3 | hFz7

Type:

PROTEIN

Mol. Mass.:

63630.03

Organism:

Homo sapiens

Description:

ChEMBL_109743

Residue:

574

Sequence:

MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI
AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC
RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYP
TAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRAN
GLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLT
WFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDA
LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTV
PATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIV
GITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV

BDBM50519306

n/a

Name

BDBM50519306

Synonyms:

CHEMBL4454406

Type

Small organic molecule

Emp. Form.

C146H194N32O42S4

Mol. Mass.

3197.552

SMILES

CCC(CC)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O)C(CC)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|

Structure