| Reaction Details |
|---|
 | Report a problem with these data |
| Target | tRNA (guanine-N(1)-)-methyltransferase |
|---|
| Ligand | BDBM50519367 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1874972 (CHEMBL4376261) |
|---|
| IC50 | 140±n/a nM |
|---|
| Citation |  Zhong, W; Pasunooti, KK; Balamkundu, S; Wong, YH; Nah, Q; Gadi, V; Gnanakalai, S; Chionh, YH; McBee, ME; Gopal, P; Lim, SH; Olivier, N; Buurman, ET; Dick, T; Liu, CF; Lescar, J; Dedon, PC Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37- J Med Chem62:7788-7805 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| tRNA (guanine-N(1)-)-methyltransferase |
|---|
| Name: | tRNA (guanine-N(1)-)-methyltransferase |
|---|
| Synonyms: | 2.1.1.228 | M1G-methyltransferase | TRMD_PSEAE | tRNA (guanine-N(1)-)-methyltransferase | tRNA [GM37] methyltransferase | trmD |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 28350.59 |
|---|
| Organism: | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
|---|
| Description: | ChEMBL_119649 |
|---|
| Residue: | 252 |
|---|
| Sequence: | MDKRLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRDYTEDRHQTVDDRPFGG
GPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRY
EGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGHADSAEEDSFTDGL
LDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQK
LLAEYIRQRDDS
|
|
|
|---|
| BDBM50519367 |
|---|
| n/a |
|---|
| Name | BDBM50519367 |
|---|
| Synonyms: | CHEMBL4437560 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H30ClN5O2S |
|---|
| Mol. Mass. | 464.024 |
|---|
| SMILES | Cl.NCCCCCCCNCc1ccc(CNC(=O)c2csc3nc[nH]c(=O)c23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
