| Reaction Details |
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 | Report a problem with these data |
| Target | GMP synthase [glutamine-hydrolyzing] |
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| Ligand | BDBM50519498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1875728 (CHEMBL4377122) |
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| IC50 | 46500±n/a nM |
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| Citation |  Cheviet, T; Lefebvre-Tournier, I; Wein, S; Peyrottes, S Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues. J Med Chem62:8365-8391 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GMP synthase [glutamine-hydrolyzing] |
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| Name: | GMP synthase [glutamine-hydrolyzing] |
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| Synonyms: | 6.3.5.2 | GMP synthase [glutamine-hydrolyzing] | GMP synthetase | GMPS | GUAA_HUMAN | Glutamine amidotransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76718.04 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_101302 |
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| Residue: | 693 |
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| Sequence: | MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP
AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHK
KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE
SKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVL
VLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAA
HSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPE
EVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVR
ILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPH
TLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDW
ESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILR
ESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVE
VVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE
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| BDBM50519498 |
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| n/a |
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| Name | BDBM50519498 |
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| Synonyms: | Decoyinine |
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| Type | Small organic molecule |
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| Emp. Form. | C11H13N5O4 |
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| Mol. Mass. | 279.252 |
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| SMILES | Nc1ncnc2n(cnc12)[C@]1(CO)OC(=C)[C@@H](O)[C@H]1O |
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| Structure | 
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