| Reaction Details |
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 | Report a problem with these data |
| Target | Mixed lineage kinase domain-like protein |
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| Ligand | BDBM5832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1877359 (CHEMBL4378753) |
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| Kd | 9300±n/a nM |
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| Citation |  Zhuang, C; Chen, F Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. J Med Chem63:1490-1510 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mixed lineage kinase domain-like protein |
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| Name: | Mixed lineage kinase domain-like protein |
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| Synonyms: | MLKL | MLKL_HUMAN | Mixed lineage kinase domain-like protein | hMLKL |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54493.57 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104428 |
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| Residue: | 471 |
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| Sequence: | MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL
PPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSI
AIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKD
LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMS
LGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKI
RKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
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| BDBM5832 |
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| n/a |
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| Name | BDBM5832 |
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| Synonyms: | 3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl})amino]phenyl}-1-[4-(trifluoromethoxy)phenyl]urea | urea deriv. 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22F3N7O4S |
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| Mol. Mass. | 573.547 |
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| SMILES | CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 |
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| Structure | 
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