| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50519746 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1878294 (CHEMBL4379688) |
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| Ki | 83±n/a nM |
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| Citation |  Malek, R; Arribas, RL; Palomino-Antolin, A; Totoson, P; Demougeot, C; Kobrlova, T; Soukup, O; Iriepa, I; Moraleda, I; Diez-Iriepa, D; Gody?, J; Panek, D; Malawska, B; G?uch-Lutwin, M; Mordyl, B; Siwek, A; Chabchoub, F; Marco-Contelles, J; Kiec-Kononowicz, K; Egea, J; de Los Ríos, C; Ismaili, L New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H J Med Chem62:11416-11422 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50519746 |
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| n/a |
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| Name | BDBM50519746 |
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| Synonyms: | CHEMBL4455698 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N2O5 |
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| Mol. Mass. | 456.5744 |
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| SMILES | CCOC(=O)C1=C(C)NC(C)=C(C1c1ccc(OCCCN2CCCC2)cc1)C(=O)OCC |c:5,10| |
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| Structure | 
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