| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisomal membrane protein PEX14 |
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| Ligand | BDBM304007 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1879207 (CHEMBL4380601) |
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| EC50 | 7250±n/a nM |
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| Citation |  Dawidowski, M; Kalel, VC; Napolitano, V; Fino, R; Schorpp, K; Emmanouilidis, L; Lenhart, D; Ostertag, M; Kaiser, M; Kolonko, M; Tippler, B; Schliebs, W; Dubin, G; Mäser, P; Tetko, IV; Hadian, K; Plettenburg, O; Erdmann, R; Sattler, M; Popowicz, GM Structure-Activity Relationship in Pyrazolo[4,3- J Med Chem63:847-879 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisomal membrane protein PEX14 |
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| Name: | Peroxisomal membrane protein PEX14 |
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| Synonyms: | PEX14 | PEX14_HUMAN | PTS1 receptor-docking protein | Peroxin-14 | Peroxisomal membrane anchor protein PEX14 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41218.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75381 |
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| Residue: | 377 |
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| Sequence: | MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTD
EEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIA
FGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQ
QQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPS
WQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGE
GVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQ
VEKLRRPEGASNESERD
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| BDBM304007 |
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| n/a |
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| Name | BDBM304007 |
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| Synonyms: | US10138242, Compound 96 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H34N6O2 |
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| Mol. Mass. | 570.6835 |
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| SMILES | COc1ccc(CN2CCc3c(C2)c(nn3CCn2ccnc2)C(=O)NCc2cccc3ccccc23)c2ccccc12 |
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| Structure | 
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