Reaction Details |
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Target | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Ligand | BDBM50520250 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1879547 (CHEMBL4380941) |
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IC50 | 87200±n/a nM |
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Citation | Kienle, M; Eisenring, P; Stoessel, B; Horlacher, OP; Hasler, S; van Colen, G; Hartkoorn, RC; Vocat, A; Cole, ST; Altmann, KH Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin. J Med Chem63:1105-1131 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
Synonyms: | Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA |
Type: | Enzyme |
Mol. Mass.: | 28526.00 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | P9WGR1 |
Residue: | 269 |
Sequence: | MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL
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BDBM50520250 |
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n/a |
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Name | BDBM50520250 |
Synonyms: | CHEMBL4575301 |
Type | Small organic molecule |
Emp. Form. | C27H34N4O8 |
Mol. Mass. | 542.5809 |
SMILES | [H][C@@]1(OC(=O)[C@H](C)[C@H](O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC1=O)[C@@H](C)CC |r| |
Structure |
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