Reaction Details |
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Target | D-alanine--D-alanine ligase |
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Ligand | BDBM50520702 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1881793 (CHEMBL4383292) |
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IC50 | 990±n/a nM |
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Citation | Ameryckx, A; Thabault, L; Pochet, L; Leimanis, S; Poupaert, JH; Wouters, J; Joris, B; Van Bambeke, F; Frédérick, R 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. Eur J Med Chem159:324-338 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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D-alanine--D-alanine ligase |
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Name: | D-alanine--D-alanine ligase |
Synonyms: | 6.3.2.4 | D-Ala-D-Ala ligase | D-alanine--D-alanine ligase | D-alanylalanine synthetase | DDL_ENTFA | ddl |
Type: | PROTEIN |
Mol. Mass.: | 39321.79 |
Organism: | Enterococcus faecalis (strain ATCC 700802 / V583) |
Description: | ChEMBL_119668 |
Residue: | 348 |
Sequence: | MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERPQNKE
VLHLTWAQTPEETGEFSGKRISPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVG
AGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKGNPKEVFEKCEGSLIYPVFVKP
ANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTLPGE
VVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTS
KNELFLNELNTMPGFTDFSMYPLLWENMGLKYSDLIEELIQLALNRFK
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BDBM50520702 |
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n/a |
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Name | BDBM50520702 |
Synonyms: | CHEMBL4451238 |
Type | Small organic molecule |
Emp. Form. | C14H12Cl2N4O2S |
Mol. Mass. | 371.242 |
SMILES | Nc1ccc(C(=O)NNC(=S)Nc2ccc(Cl)c(Cl)c2)c(O)c1 |
Structure |
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