| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein |
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| Ligand | BDBM50075608 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_161098 (CHEMBL771559) |
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| EC50 | 190±n/a nM |
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| Citation |  Dragovich, PS; Prins, TJ; Zhou, R; Fuhrman, SA; Patick, AK; Matthews, DA; Ford, CE; Meador, JW; Ferre, RA; Worland, ST Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem42:1203-12 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein |
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| Name: | Genome polyprotein |
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| Synonyms: | Human rhinovirus A protease | Human rhinovirus B 3A protease |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44361.04 |
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| Organism: | Human rhinovirus B |
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| Description: | ChEMBL_158953 |
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| Residue: | 401 |
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| Sequence: | AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMS
AIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIA
NIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVIT
TGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDR
NEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYN
YPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQT
IHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
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| BDBM50075608 |
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| n/a |
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| Name | BDBM50075608 |
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| Synonyms: | (E)-(S)-4-((2R,5S)-2-Benzyl-5-benzylsulfanylcarbonylamino-6-methyl-4-oxo-heptanoylamino)-6-carbamoyl-hex-2-enoic acid ethyl ester | CHEMBL279889 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41N3O6S |
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| Mol. Mass. | 595.749 |
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| SMILES | CCOC(=O)\C=C\[C@H](CCC(N)=O)NC(=O)[C@@H](CC(=O)[C@@H](NC(=O)SCc1ccccc1)C(C)C)Cc1ccccc1 |
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| Structure | 
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